Ladies: SAMe/whey or hot love making - you decide!

Hi everyone,

The male brain stinks! I'm not speaking figuratively. Males literally have brains that smell like rotten eggs. The rotten egg smell is hydrogen sulfide (H2S). (1) indicates that testosterone increases the production of H2S in the brain.

This topic is the most under-researched of any topic I've ever reviewed. We're talking Nobel prize winning material is still out there waiting to be studied. Brain H2S may account for many of the differences between men and women.

Yet, there is very little in the literature about the significance of this difference. But, from what little is available it appears that low H2S harms our ability to learn and makes us prone to depression. It also leads to a sensitivity to glutamate as in MSG which I've observed.

H2S may be elevated in the feminized brain by consuming more cysteine which is most available in undentatured whey protein. Cysteine will also elevate the level of glutathione in the brain leading to one having more psychological energy. Elevating glutathione is also useful for people with chronic fatigue (http://www.dfwcfids.org/medical/whey.html) and related problems like fibromyalgia. Warning - some sources mention a brief worsening of symptoms may happen after taking whey. Ride these through and whey may help.

Some companies selling "undenatured whey" products are misleading the public and are not doing so. Two undenatured whey products which appear to be legitimate are the following:

ProPeptide by CNP - available many places. http://www.affordablesupplements.com/propeptide.asp has a good price.

Beyond a Century brand - the 90% whey seems the best bang for our buck. See http://www.easycart.net/BeyondACenturyInc./Protein_Meal_Replacement.html .

A reputable health food store can provide similar products. I advise avoiding the health food chain stores due to the questionable quality of their products and lack of knowledge of their staffs.

H2S may also be increased by taking the natural anti-depressant S-adenosyl-L-methionine (SAMe).

SAMe effects join my increasingly long list of female beneficial substances which involve semen. (3) points out that SAMe works in part by elevating spermidine and spermine in the brain. You can tell by the names of these compounds that they are associated with semen. Putrescine, also elevated by SAMe, is in semen also. So, semen provides all these beneficial compounds and elevates H2S too.

Research in this and other areas over-whelmingly supports my contention that biogals and male to female transsexuals on feminizing drug treatment function best if they have regular unprotected sex with men. Obviously, this only the case if we avoid catching a serious disease we'd be best off without.

(4) agrees with me about the value of semen when it comes to relieving depression. My contention is the woman who is not into having unprotected sex with men, or who couldn't get a man if she payed one, can compensate by taking SAMe and consuming undenatured whey protein.

1. J Neurochem. 2002 Oct;83(1):80-6 The production of hydrogen sulfide is regulated by testosterone and S-adenosyl-L-methionine in mouse brain. Eto K, Kimura H. National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan. Hydrogen sulfide (H2S) is endogenously produced in the brain from L-cysteine by the enzyme cystathionine beta-synthase (CBS) and functions as a neuromodulator in the brain. H2S selectively enhances NMDA receptor-mediated responses and alters hippocampal long-term potentiation (LTP). The production of H2S is regulated by Ca2+/calmodulin-mediated pathways and is enhanced in response to neuronal excitation. In addition to this fast regulation, we describe here a slower form of the regulation of H2S production by testosterone and S-adenosyl-L-methionine (SAM), a CBS activator. Endogenous H2S in the mouse brain increases after birth, reaches a maximum level at 8 weeks and then decreases. Female brain contains less H2S than male brain at each age. A single administration of testosterone to female mice increases the endogenous H2S and SAM, which reach levels similar to those of male mice. In contrast, castration of male mice decreases the levels of testosterone, SAM and H2S in the brain. Administration of SAM once a day for 3 days increases the brain H2S without significantly changing the testosterone level. These observations suggest that testosterone can regulate the brain H2S level via changing the level of SAM. PMID: 12358731

2. http://www.cassmd.com/library/SAMe.support.html SAMe for Depression...and Arthritis and Liver Support ... What is SAMe? SAMe, or s-adenosyl-methionine is a naturally occurring substance in the body, with the following uses:

It is used in the production of the feel-good neurotransmitters, the chemical messengers in the brain that mediate our mood. These include dopamine, norepinephrine, and serotonin. ... SAMe has also been shown to protect the liver and body from the effects of excess and unbalanced estrogen levels, seen in some estrogen replacement therapy, oral contraceptive use, and premenstrual syndrome. ... SAMe's antidepressant activity may lead to the manic phase in individuals with bipolar (manic) depression.

3. Neuroreport. 2001 Dec 21;12(18):3939-42 Influence of SAMe on the modifications of brain polyamine levels in an animal model of depression. Genedani S, Saltini S, Benelli A, Filaferro M, Bertolini A. Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, Via G. Campi 287, 41100 Modena, Italy. The mechanism(s) of the antidepressant activity of S-adenosyl-L-methionine (SAMe) have not yet been elucidated. SAMe is essential for the synthesis of polyamines, which have a key role in protein synthesis, cell proliferation, and neuronal plasticity. On the other hand, accumulating data indicate that depression is associated with a reduction in regional brain volume and that antidepressants increase neurogenesis in defined brain regions and also influence neuronal plasticity. Here we show that in a validated rat model of depression (chronic unpredictable mild stress-induced anhedonia) there is a significant reduction of putrescine, spermidine and spermine in the hippocampus, and of only putrescine in the nucleus accumbens septi. SAMe, at a fully antidepressant dose (300 mg/kg i.m., daily for 7 days), completely restores the levels of putrescine in the nucleus accumbens, and restores in part the levels of both spermidine and spermine in the hippocampus. These results may suggest (i) a role for brain polyamines in depression and in reward processes, and (ii) that the antidepressant effect of SAMe may be due, at least in part, to a normalization of putrescine levels in the nucleus accumbens septi. PMID: 11742215

4. http://psychologytoday.com/articles/pto-20021002-000009.html Crying Over Spilled Semen Why women who don't use condoms feel happier. By:Tiffany Kary The finding that women who do not use condoms during sex are less depressed and less likely to attempt suicide than are women who have sex with condoms and women who are not sexually active, leads one researcher to conclude that semen contains powerful—and potentially addictive—mood-altering chemicals.

Study author Gordon G. Gallup, Ph.D., a psychologist at the State University of New York in Albany, also found that women who routinely had intercourse without condoms became increasingly depressed as more time elapsed since their last sexual encounter. There was no such correlation for women whose partners regularly used condoms.

Nerissa